The Adventures of Ozzie and Harriet aired on ABC from October 3, 1952 to September 3, 1966, starring the real life Nelson family. The series starred Ozzie Nelson and his wife, singer Harriet Nelson, and their young sons, David Nelson and Eric Nelson, better known as Ricky. Don DeFore had a recurring role as the Nelsons' friendly neighbor "Thorny". The series attracted large audiences, and although it was never a top-ten hit, it became synonymous with the 1950s ideal American family life. It is the longest-running "live-action"/non-animated sitcom in US TV history.

When Red Skelton was drafted in March 1944, Ozzie Nelson was prompted to create his own family situation comedy. The Adventures of Ozzie and Harriet launched on CBS on October 8, 1944, making a mid-season switch to NBC in 1949. The final years of the radio series were on ABC (the former NBC Blue Network) from October 14, 1949 to June 18, 1954. In total 402 radio episodes were produced. In an arrangement that amplified the growing pains of American broadcasting, as radio "grew up" into television, the Nelsons' deal with ABC gave the network the option to move their program to television. The struggling network needed proven talent that was not about to defect to the more established and wealthier networks like CBS or NBC.

Before the show aired, Ozzie Nelson persuaded ABC to agree to a 10-year contract that paid whether the series was canceled or not. The unprecedented contract and Ozzie's insistence for perfection in the show's production paid off in the show's remarkable popularity.

The Adventures of Ozzie and Harriet premiered on ABC on October 10, 1952, staying until September 3, 1966. The show strove for realism and featured exterior shots of the Nelsons' actual southern California home as the fictional Nelsons' home. Interior shots were filmed on a sound stage recreated to look like the real interior of the Nelsons' home. Like its radio predecessor, the series focused mainly on the Nelson family at home, dealing with run-of-the-mill problems. As the series progressed and the boys grew up, storylines involving various characters were introduced. Many of the series storylines were taken from the Nelsons' real life. When the real David and Rick got married, to June Blair and Kristin Harmon respectively, their wives joined the cast of Ozzie and Harriet, and the marriages were written into the series.