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Thanks to sharp writing and a pitch-perfect ensemble cast, Frasier became one of the smartest and funniest television shows of the 1990s. Following the 1993 demise of Cheers, Diane's fussy psychiatrist boyfriend, Frasier Crane (Kelsey Grammer), seemed an unlikely candidate for a spin-off series, yet the show earned smash ratings and dozens of Emmy Awards, including Outstanding Comedy Series and Outstanding Lead Actor (Grammer) in the very first season.

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Frasier picked up its second season with another round of comedy as intelligent as its pompous title character. Fortunately, the sniping between Frasier (Kelsey Grammer) and his father, Marty (John Mahoney), that took up a lot of the first season is mostly past, and the crack ensemble was ready to roll in a number of memorable episodes. Frasier tries to set up Daphne (Jane Leeves) with the new station manager in "The Matchmaker," Frasier, Niles (David Hyde Pierce), and Marty go fishing in "Breaking the Ice," Frasier and Niles jump into politics in "The Candidate," the team of Frasier and Roz (Peri Gilpin) breaks up ("Roz in the Doghouse"), and Frasier and Niles open a restaurant in "The Innkeepers."

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With this third season, Frasier scored an impressive hat trick, winning its third successive Emmy for Outstanding Comedy Series. You don't need too much analysis to get to the bottom of this unprecedented success.

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Frasier's fourth season was mostly about relationships. Niles (David Hyde Pierce), now separated from Maris, is back on the market like his bachelor brother, Frasier (Kelsey Grammer). That's great when the pair goes to a cabin with a pair of fetching women (Megan Mullaly, later of Will and Grace, and Lisa Darr), but Niles is never able to completely dispel his attachment to his suffocating wife... or to Daphne (Jane Leeves).

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Frasier's fifth season is marked by two central themes. First is Roz's (Peri Gilpin) unexpected pregnancy, which naturally opens the door for countless promiscuity jokes for the radio show's beleaguered producer. The second is the continuing drama of Niles (David Hyde Pierce) and his frosty wife, Maris, which seemed to finally come to a head. Not that even a good marriage has ever kept Niles from pining for Daphne (Jane Leeves), of course.

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This is the pivotal season that finally, finally brings together Niles (David Hyde Pierce) and Daphne (Jane Leeves), Frasier's answer to Ross and Rachel. Daphne, engaged to Donny (Saul Rubinek), learns of Niles' unrequited feelings for her from an extremely medicated Frasier in "Back Talk." If Daphne's impending marriage was not obstacle enough to keep them apart, there is fussy, phobic, and formidable Dr. Mel Karnofsky (Jane Adams), Maris's former plastic surgeon, who is introduced in "The Late Dr. Crane" as a romantic interest for Niles.

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Seemingly not content to win all those Emmys for Outstanding Comedy Series, Frasier made a convincing bid in its eighth season for Best Drama. Make no mistake, Frasier still serves up its unique blend of sophisticated wit and farce with the usual panache. But season 8 finds Frasier (Kelsey Grammer) in a contemplative mood and mid-life crisis mode. The episode "Frasier's Edge" resonates throughout the season, as a lifetime achievement award and a suspect (only to Frasier) congratulatory note from a mentor sends him into a characteristic tailspin.

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After a distinguished run of Emmy-winning seasons, Frasier is, by its ninth season, in something of "a tiny lull" (as Frasier describes the state of his radio talk show career in the episode "Junior Agent") when its guest stars took home more Emmys than the much-decorated ensemble (Anthony LaPlaglia, reprising his role as Daphne's besotted brother, Simon, in the two-parter, "Mother Load").

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"Irritating, but endearing." That's Frasier Crane in a nutshell, as diagnosed by Julia Wilcox (an Emmy-worthy Felicity Huffman), KCAL's abrasive and condescending new financial analyst. That's a delicate balance, but Kelsey Grammer still manages it with the usual aplomb in Frasier's penultimate season.

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Midway through Frasier's redemptive final season (which earned Emmys for Kelsey Grammer and David Hyde Pierce), Martin Crane (John Mahoney) reassures his son, "Just when you think that you're in a rut and nothing exciting will ever happen again, pow, that's when it does." The same could have been said of Frasier's redemptive final season. Not that the multi-Emmy-honored series had ever really jumped the couch, but by its 11th season, it had lost some of its sparkle.